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Results for "

arginine methyltransferase

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Histone Methyltransferase (41) Apoptosis (2) CDK (1) MDM-2/p53 (1) Parasite (2) Phosphodiesterase (PDE) (2) PROTACs (1) SARS-CoV (1)
By Research Areas:	Cancer (41) Infection (3) Inflammation/Immunology (3) Metabolic Disease (1)

Inhibitors & Agonists

Screening Libraries

Peptides

Recombinant Proteins

Targets Recommended: Protein Arginine Deiminase Histone Methyltransferase DNA Methyltransferase SRPK COMT ICMT METTL3

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-111213

PRMT5-IN-20

Histone Methyltransferase Cancer

PRMT5-IN-20 is a selective protein arginine methyltransferase 5 (PRMT5) inhibitor with anti-tumor activity .
HY-109963

PR5-LL-CM01

Histone Methyltransferase Cancer

PR5-LL-CM01 is a potent protein arginine methyltransferase 5 (PRMT5) inhibitor (IC₅₀= 7.5 μM). Anti-tumor activies .

PRMT5-IN-20	Histone Methyltransferase	Cancer
PRMT5-IN-20 is a selective protein arginine methyltransferase 5 (PRMT5) inhibitor with anti-tumor activity .

PR5-LL-CM01	Histone Methyltransferase	Cancer
PR5-LL-CM01 is a potent protein arginine methyltransferase 5 (PRMT5) inhibitor (IC₅₀= 7.5 μM). Anti-tumor activies .

HY-144187

PRMT5-IN-16	Histone Methyltransferase	Cancer
PRMT5-IN-16 (Compound 20) is a PRMT5 inhibitor with anti-tumor activity. PRMT5 is a type of protein arginine methyltransferase, and is a new anti-tumor target related to epigenetic modification .

HY-144188

PRMT5-IN-17	Histone Methyltransferase	Cancer
PRMT5-IN-17 (Compound 6) is a PRMT5 inhibitor with anti-tumor activity. PRMT5 is a type of protein arginine methyltransferase, and is a new anti-tumor target related to epigenetic modification .

HY-P3822

PRMT5-IN-23	Histone Methyltransferase	Cancer
PRMT5-IN-23 (compound 50) is an inhibitor of *protein arginine* methyltransferase 5 (PRMT5) with anti-tumor activity. PRMT5** is a type of protein arginine methyltransferase, and is a new anti-tumor target related to epigenetic modification .

HY-110158

UNC2327

Histone Methyltransferase Cancer

UNC2327 is an allosteric inhibitor of protein arginine methyltransferase 3 (PRMT3).

UNC2327	Histone Methyltransferase	Cancer
UNC2327 is an allosteric inhibitor of protein arginine methyltransferase 3 (PRMT3).

HY-100025A

HLCL-61 hydrochloride 2 Publications Verification	Histone Methyltransferase Apoptosis	Cancer
HLCL-61 hydrochloride is a first-in-class inhibitor of *protein arginine* methyltransferase 5 (PRMT5)**.

HY-111109

EZM 2302 5 Publications Verification	Histone Methyltransferase	Cancer
EZM 2302 is an inhibitor of coactivator-associated arginine methyltransferase 1 (CARM1) with an IC₅₀ of 6 nM.

HY-141875

PRMT5-IN-13

Histone Methyltransferase Cancer

PRMT5-IN-13 is a selective inhibitor of protein arginine methyltransferase 5 (prmt5).

PRMT5-IN-13	Histone Methyltransferase	Cancer
PRMT5-IN-13 is a selective inhibitor of *protein arginine* methyltransferase 5 (prmt5)**.

HY-133740

MS117	Histone Methyltransferase	Cancer
MS117 is a first-in-class and cell-active irreversible *protein arginine* methyltransferase 6 (PRMT6) covalent inhibitor, with an IC₅₀** of 18 nM .

HY-19715

SGC707 5+ Cited Publications	Histone Methyltransferase	Metabolic Disease
SGC707 is a potent, selective, and non-competitive PRMT3 (*protein arginine* methyltransferase 3) inhibitor (IC₅₀=31 nM, K_d**=53 nM).

HY-112165

PRMT5-IN-2

Histone Methyltransferase Cancer

PRMT5-IN-2 is a rotein arginine methyltransferase 5 (PRMT5) inhibitor extracted from patent WO2018130840A1, compound 3 .

PRMT5-IN-2	Histone Methyltransferase	Cancer
PRMT5-IN-2 is a *rotein arginine* methyltransferase 5 (PRMT5)** inhibitor extracted from patent WO2018130840A1, compound 3 .

HY-155154A

PRMT4-IN-3	Histone Methyltransferase	Cancer
PRMT4-IN-3 (compound 56) is a potent inhibitor of class I protein arginine methyltransferase (PRMT), targeting PRMT4 (IC₅₀: 37 nM) and PRMT4 (IC₅₀: 253 nM) .

HY-107777

LLY-283 2 Publications Verification	Histone Methyltransferase	Cancer
LLY-283 is a potent, selective and oral protein arginine methyltransferase 5 (PRMT5) inhibitor, with an IC₅₀ of 22 nM and a K_d of 6 nM for PRMT5:MEP50 complex, and shows antitumor activity.

HY-101564

Onametostat 4 Publications Verification JNJ-64619178	Histone Methyltransferase	Cancer
Onametostat (JNJ-64619178) is a selective, orally active and pseudo-irreversible *protein arginine* methyltransferase 5 (PRMT5) inhibitor with an IC₅₀** of 0.14 nM. Onametostat has potent activity in lung cancer .

HY-12759A

CARM1-IN-1 hydrochloride 1 Publications Verification	Histone Methyltransferase	Cancer
CARM1-IN-1 hydrochloride is a potent and specific CARM1 (Coactivator-associated arginine methyltransferase 1) inhibitor with IC₅₀ of 8.6 uM; shows very low activity against PRMT1 and SET7.

HY-141877B

MS4322 (isomer) YS43-22 (isomer)	PROTACs	Cancer
MS4322 (YS43-22) isomer is an isomer of MS4322. MS4322 is a potent and selective PRMT5 (*protein arginine* methyltransferase 5**) degrader, and inhibits growth of multiple cancer cell lines .

HY-100565

SGC2085 1 Publications Verification	Histone Methyltransferase	Cancer
SGC2085 is a potent and selective inhibitor of coactivator associated arginine methyltransferase 1 (CARM1) with an IC₅₀ of 50 nM. SGC2085 also selectively inhibits PRMT6 with an IC₅₀ value of 5.2 μM, but not other PRMT proteins .

HY-15214A

CARM1-IN-3 dihydrochloride	Histone Methyltransferase	Cancer
CARM1-IN-3 dihydrochloride (compound 17b) is a potent and selective *co-activator associated arginine* methyltransferase (CARM1) inhibitor with IC₅₀** values of 0.07, >25 µM for CARM1 and CARM3, respectively .

HY-100565A

SGC2085 hydrochloride	Histone Methyltransferase
SGC2085 hydrochloride is a potent and selective inhibitor of coactivator associated arginine methyltransferase 1 (CARM1) with an IC₅₀ of 50 nM. SGC2085 hydrochloride also selectively inhibits PRMT6 with an IC₅₀ value of 5.2 μM, but not other PRMT proteins .

HY-15214

CARM1-IN-3	Histone Methyltransferase	Cancer
CARM1-IN-3 (compound 17b) is a potent and selective *co-activator associated arginine* methyltransferase (CARM1) inhibitor with IC₅₀** values of 0.07, >25 µM for CARM1 and CARM3, respectively .

HY-Q36691

PRMT5-IN-30	Histone Methyltransferase	Cancer
PRMT5-IN-30 (compound 17) is a potent and selective *protein arginine* methyltransferase 5 (PRMT5) inhibitor with an IC₅₀ of 0.33 μM and a K_d** of 0.987 μM. PRMT5-IN-30 exhibits a broad selectivity against a panel of other methyltransferases. PRMT5-IN-30 inhibits PRMT5 mediated SmD3 methylation .

HY-122096

DCLX069 1 Publications Verification	Histone Methyltransferase	Cancer
DCLX069 is a selective *protein arginine* methyltransferase 1 (PRMT1) inhibitor with an IC₅₀** value of 17.9 µM. DCLX069 shows less active against PRMT4 and PRMT6. DCLX069 has anticancer effects .

HY-153421

PRMT5-IN-28	Histone Methyltransferase	Cancer
PRMT5-IN-28 (compound 36) is an inhibitor of *protein arginine* methyltransferase 5 (PRMT5*) enzyme. Protein arginine* methylation is a common post-translational modification involved in gene transcription, mRNA splicing, DNA repair, protein cellular localization, cell fate determination and signal transduction, etc. Abnormal PRMT5 can promote cancer cell proliferation, resist apoptosis, enhance invasion and metastasis, and affect immune escape .

HY-155154

PRMT4-IN-2	Others	Cancer
PRMT4-IN-2 (compound 55) is a pan-inhibitor of protein arginine methyltransferase (PRMT) with IC₅₀s of 92 nM (PRMT4), 436 nM (PRMT6), 460 nM (PRMT1), 823 nM ( PRMT8), 1.386 μM (PRMT3) .

HY-12759

CARM1-IN-1 1 Publications Verification	Histone Methyltransferase	Cancer
CARM1-IN-1 is a potent and specific CARM1(Coactivator-associated arginine methyltransferase 1) inhibitor with IC50 of 8.6 uM; shows very low activity against PRMT1 and SET7(IC50 > 600 uM).

HY-19615

MS023 5+ Cited Publications	Histone Methyltransferase	Cancer
MS023 is a potent, selective, and cell-active inhibitor of human *type I protein arginine* methyltransferases (PRMTs) inhibitor, with IC₅₀s of 30, 119, 83, 4 and 5 nM for PRMT1, PRMT3, PRMT4, PRMT6, and PRMT8**, respectively .

HY-19615B

MS023 dihydrochloride 5+ Cited Publications	Histone Methyltransferase	Cancer
MS023 dihydrochloride is a potent, selective, and cell-active inhibitor of human *type I protein arginine* methyltransferases (PRMTs) inhibitor, with IC₅₀s of 30, 119, 83, 4 and 5 nM for PRMT1, PRMT3, PRMT4, PRMT6, and PRMT8**, respectively .

HY-19615A

MS023 trihydrochloride	Histone Methyltransferase	Cancer
MS023 trihydrochloride is a potent, selective, and cell-active inhibitor of human *type I protein arginine* methyltransferases (PRMTs) inhibitor, with IC₅₀s of 30, 119, 83, 4 and 5 nM for PRMT1, PRMT3, PRMT4, PRMT6, and PRMT8**, respectively .

HY-128717

GSK3368715 EPZ019997	Histone Methyltransferase	Cancer
GSK3368715 (EPZ019997) is an orally active, reversible, and S-adenosyl-L-methionine (SAM) uncompetitive *type I protein arginine* methyltransferases (PRMTs) inhibitor (IC₅₀*=3.1 nM (PRMT1), 48 nM (PRMT3), 1148 nM (PRMT4), 5.7 nM (PRMT6), 1.7 nM (PRMT8)). GSK3368715 (EPZ019997) produces a shift in arginine* methylation states, alters exon usage, and has strong anti-cancer activity .

HY-128717A

GSK3368715 dihydrochloride 10+ Cited Publications EPZ019997 dihydrochloride	Histone Methyltransferase	Cancer
GSK3368715 dihydrochloride (EPZ019997 dihydrochloride) is an orally active, reversible, and S-adenosyl-L-methionine (SAM) uncompetitive *type I protein arginine* methyltransferases (PRMTs) inhibitor (IC₅₀*=3.1 nM (PRMT1), 48 nM (PRMT3), 1148 nM (PRMT4), 5.7 nM (PRMT6), 1.7 nM (PRMT8)). GSK3368715 dihydrochloride (EPZ019997 dihydrochloride) produces a shift in arginine* methylation states, alters exon usage, and has strong anti-cancer activity .

HY-128717B

GSK3368715 trihydrochloride EPZ019997 trihydrochloride	Histone Methyltransferase	Cancer
GSK3368715 trihydrochloride (EPZ019997) is an orally active, reversible, and S-adenosyl-L-methionine (SAM) uncompetitive *type I protein arginine* methyltransferases (PRMTs) inhibitor (IC₅₀*=3.1 nM (PRMT1), 48 nM (PRMT3), 1148 nM (PRMT4), 5.7 nM (PRMT6), 1.7 nM (PRMT8)). GSK3368715 trihydrochloride (EPZ019997) produces a shift in arginine* methylation states, alters exon usage, and has strong anti-cancer activity .

HY-128579

DW14800	Histone Methyltransferase	Cancer
DW14800 is a protein arginine methyltransferase 5 (PRMT5) inhibitor, with an IC₅₀ of 17 nM. DW14800 reduces H4R3me2s levels and enhances the transcription of HNF4α, but does not alter PRMT5 expression. Anti-cancer activity .

HY-126256

PRMT5-IN-1	Histone Methyltransferase	Cancer
PRMT5 IN-1, a hemiaminal, is a potent, selective *protein arginine* methyltransferase 5 (PRMT5) inhibitor with an IC₅₀** of 11 nM for PRMT5/MEP50. PRMT5 IN-1 can be converted to aldehydes and react with C449 to form covalent adducts under physiological conditions .

HY-18962

AMI-1	Histone Methyltransferase	Cancer
AMI-1 is a potent, cell-permeable and reversible inhibitor of *protein arginine* N-methyltransferases (PRMTs), with IC₅₀**s of 8.8 μM and 3.0 μM for human PRMT1 and yeast-Hmt1p, respectively. AMI-1 exerts PRMTs inhibitory effects by blocking peptide-substrate binding .

HY-100855

DC_C66	Histone Methyltransferase	Cancer
DC_C66 is a cell-permeable, selective *coactivator associated arginine* methyltransferase 1 (CARM1) inhibitor with an IC₅₀ of 1.8 μM. DC_C66 has a good selectivity for CARM1 against PRMT1 (IC₅₀=21 μM), PRMT6 (IC₅₀**= 47μM), and PRMT5 .

HY-126256A

PRMT5-IN-1 hydrochloride	Histone Methyltransferase	Cancer
PRMT5 IN-1 hydrochloride (compound 9), a hemiaminal, is a potent, selective *protein arginine* methyltransferase 5 (PRMT5) inhibitor with an IC₅₀** of 11 nM for PRMT5/MEP50. PRMT5 IN-1 hydrochloride can be converted to aldehydes and react with C449 to form covalent adducts under physiological conditions .

HY-124131

DS-437	Histone Methyltransferase	Inflammation/Immunology Cancer
DS-437 is a dual PRMT5/7 inhibitor (IC₅₀s of PRMT5/7=6 μM). DS-437 is selective for PRMT5 and PRMT7 over 29 other human protein-, DNA-, and RNA-methyltransferases. DS-437 is a S-adenosylmethionine (SAM)-competitive inhibitor of PRMT5. DS-437 also inhibits DNMT3A and DNMT3B, with IC₅₀s of 52 and 62 μM, respectively. DS-437 inhibits the methylation of FOXP3 .

HY-18962A

AMI-1 free acid 3 Publications Verification	Histone Methyltransferase	Cancer
AMI-1 free acid is a potent, cell-permeable and reversible inhibitor of *protein arginine* N-methyltransferases (PRMTs), with IC₅₀**s of 8.8 μM and 3.0 μM for human PRMT1 and yeast-Hmt1p, respectively. AMI-1 free acid exerts PRMTs inhibitory effects by blocking peptide-substrate binding .

HY-101563

GSK3326595 Maximum Cited Publications 15 Publications Verification EPZ015938	Histone Methyltransferase SARS-CoV MDM-2/p53 CDK Apoptosis	Infection Cancer
GSK3326595 is a protein arginine methyltransferase 5 (PRMT5) inhibitor. GSK3326595 decreases SARS-CoV-2 infection, inhibits cancer cell proliferation and induces pro-inflammatory macrophage polarization and increases hepatic triglyceride levels without affecting atherosclerosis. GSK3326595 can be used for research of relapsed/refractory mantle cell lymphoma .

HY-P1182

C21

Histone Methyltransferase Cancer

C21 is a potent, irreversible, and selective PRMT1 inhibitor with an IC₅₀ of 1.8 μM. C21 inhibits PRMT6 with an IC₅₀ of 8.8 μM .

C21	Histone Methyltransferase	Cancer
C21 is a potent, irreversible, and selective PRMT1 inhibitor with an IC₅₀ of 1.8 μM. C21 inhibits PRMT6 with an IC₅₀ of 8.8 μM .

HY-110137A

Furamidine DB75; NSC 305831	Histone Methyltransferase Phosphodiesterase (PDE) Parasite	Infection Inflammation/Immunology Cancer
Furamidine (DB75) is a selective *protein arginine* methyltransferase 1 (PRMT1) inhibitor with an IC₅₀ of 9.4 μM. Furamidine is selective for PRMT1 over PRMT5, PRMT6, and PRMT4 (CARM1) (IC₅₀s of 166 µM, 283 µM, and >400 µM, respectively). Furamidine is a potent, reversible and competitive tyrosyl-DNA phosphodiesterase 1 (TDP-1) inhibitor. Inhibition of TDP-1** by Furamidine is effective both with single- and double-stranded DNA substrates but is slightly stronger with the duplex DNA. Furamidine is also an antiparasite agent .

HY-110137

Furamidine dihydrochloride 1 Publications Verification DB75 dihydrochloride; NSC 305831 dihydrochloride	Histone Methyltransferase Phosphodiesterase (PDE) Parasite	Infection Inflammation/Immunology Cancer
Furamidine dihydrochloride (DB75 dihydrochloride) is a selective *protein arginine* methyltransferase 1 (PRMT1) inhibitor with an IC₅₀ of 9.4 μM. Furamidine dihydrochloride is selective for PRMT1 over PRMT5, PRMT6, and PRMT4 (CARM1) (IC₅₀s of 166 µM, 283 µM, and >400 µM, respectively). Furamidine dihydrochloride is a potent, reversible and competitive tyrosyl-DNA phosphodiesterase 1 (TDP-1) inhibitor. Inhibition of TDP-1** by Furamidine dihydrochloride is effective both with single- and double-stranded DNA substrates but is slightly stronger with the duplex DNA. Furamidine dihydrochloride is also an antiparasite agent .

Histone Modification Research Compound Library	614 compounds
A histone modification, a covalent post-translational modification (PTM) to histone proteins, includes methylation, phosphorylation, acetylation, ubiquitylation, and sumoylation, etc. In general, histone modifications are catalyzed by specific enzymes that act predominantly at the histone N-terminal tails involving amino acids such as lysine or arginine, as well as serine, threonine, tyrosine, etc. The PTMs made to histones can impact gene expression by altering chromatin structure or recruiting histone modifiers. Histone modifications act in diverse biological processes such as transcriptional activation/inactivation, chromosome packaging, and DNA damage/repair. Deregulation of histone modification contributes to many diseases, including cancer and autoimmune diseases. MCE owns a unique collection of 614 bioactive compounds targeting Epigenetic Reader Domain, HDAC, Histone Acetyltransferase, Histone Demethylase, Histone Methyltransferase, Sirtuin, etc. Histone Modification Research Compound Library is a useful tool for histone modification research and drug screening.

Species:	Human (2)
Tag:	His (2) Flag (1)
Source:	HEK293 (1) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source

HY-P76551

	PRMT3 Protein, Human (His) Protein arginine N-methyltransferase 3; PRMT3; HRMT1L3	Human	E. coli
	PRMT3 protein is a multifunctional protein arginine N-methyltransferase. As a type I methyltransferase, it catalyzes monomethylation and asymmetric dimethylation of arginine residues in target proteins. In addition to its methyltransferase role, PRMT3 may also regulate retinoic acid synthesis and signaling by inhibiting ALDH1A1 retinal dehydrogenase activity. PRMT3 Protein, Human (His) is the recombinant human-derived PRMT3 protein, expressed by E. coli , with N-10*His labeled tag. The total length of PRMT3 Protein, Human (His) is 530 a.a., with molecular weight of ~65 kDa.

HY-P75983

	PRMT6 Protein, Human (HEK293, His-Flag) Protein arginine N-methyltransferase 6; PRMT6; HRMT1L6	Human	HEK293
	PRMT6, a versatile arginine methyltransferase, prefers asymmetrical dimethylarginine (aDMA) formation and methylates arginine residues within a glycine and arginine-rich domain. It orchestrates asymmetric dimethylation of histone H3 'Arg-2,' leading to H3R2me2a, a unique epigenetic tag associated with transcriptional repression. PRMT6 serves as a transcriptional repressor for various genes, including HOXA2, THBS1, and TP53, inhibiting cellular senescence by repressing TP53. It also methylates histones H2A and H4 'Arg-3,' acts as a coactivator for steroid hormone receptors, regulates alternative splicing, and plays a role in innate immunity against HIV-1. PRMT6 Protein, Human (HEK293, His-Flag) is the recombinant human-derived PRMT6 protein, expressed by HEK293, with N-Flag, C-His labeled tag. The total length of PRMT6 Protein, Human (HEK293, His-Flag) is 375 a.a., with molecular weight of 43-46 kDa.

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